Restoration of the human skin microbiome following immune recovery after hematopoietic stem cell transplantation
- arejdala
- Jul 30
- 1 min read
New publication for You Che and collaborators on Cell Host & Microbe that explores the human immune system’s critical role in affecting the skin microbiota.

Abstract
The human skin microbiome is intricately intertwined with host immunity. While studies have elucidated microbial influences on immunity, understanding how immune alterations modulate this equilibrium remains limited.
We investigated the dual impact of immune deficiency and hematopoietic stem cell transplantation (HSCT) on the skin microbiome in 24 patients with dedicator of cytokinesis 8 (DOCK8) deficiency, a rare inborn error of immunity. Analyzing 590 metagenomic and 534 16S rDNA sequencing samples across eight skin sites, we observed disrupted microbiota pre-HSCT (median eukaryotic viruses 67.6% vs. 0.04% in controls), with extremely diverse human papillomaviruses (HPVs) and polyomaviruses including oncogenic viruses.
Specific bacterial species markedly changed, including decreased Staphylococcus aureus post-HSCT. DNA eukaryotic viruses dramatically decreased (79.7% ± 28.3% to 4.9% ± 8.6%; p < 0.01) 12 months post-HSCT. Recovered microbial communities remained relatively stable through 1-year follow-up with clearance of oncogenic HPV and no convergence with transplant donors. These results highlight the immune system’s critical role in restoring microbial balance and skin health.
You CHE’s group welcomes collaborations in the study of skin and gut microbiomes across diverse cohorts. If you are interested in exploring the role of the microbiome in human health or related areas, we invite you to get in touch.
For collaboration opportunities or more information, please contact Dr. You Che at youche@hku.hk.