The main objective of the workshop is to celebrate the 50th anniversary of the Replicon Theory by Jacob, Brenner and Cuzin. The simple idea that replicator (origin of replication) and initiator (protein) promotes initiation of DNA replication once per cell cycle, provides the paradigm for DNA replication in almost all organisms. The model also predicts a close link between replication and partition, involving chromosomal organization and membranes associated factors. A half-century after the Theory emerged, it has now been validated through repeated testing. The development of sophisticated methods in biochemistry, biophysics, molecular and cellular biology and system biology has allowed researchers to significantly advance understanding of DNA replication dynamics and its biological impact on genome stability and development. In this anniversary celebration, researchers will review present-day knowledge and share unpublished experimental data, with the aim of stimulating the emergence of new concepts. The meeting will take place at the Institut Pasteur, in the heart of Paris!
Benoit Arcangioli, Institut Pasteur, Paris, France Organizing Committee
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Celebrating the 50th Anniversary of the Replicon Theory
Date: 25-28 March 2013
Venue: Centre d'Information Scientifique (CIS), Institut Pasteur, Paris , France
Deadline for registration & abstract submission: February 1st , 2013
Registration: Early registration up to February 11, 2013: Standard fee: 250 € ; Student fee: 180 €
On line registration: http://www.pepss.com/gti/0361/GTI_361_PASTEUR_WEB/183/
Call for abstracts: https://webistem.com/bin/adm?dir=replicon2013&lang=1&opt=210
S1: Replicon's theory S2: Initiators S3: Replicators S4: Partition S5: Nuclear organization and Replication S6: Genetic stabiliy and replication S7: Replication and differentiation