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Post doc position opened in Lyssavirus dynamics and host adaptation Unit, Institut Pasteur, France

The Institut Pasteur, a non-profit private foundation that contributes to research in biology, is looking for a Post Doctoral fellow in molecular and cellular biology of Lyssavirus infection headed by Dr Hervé BOURHY.

Description The capacity of zoonotic RNA viruses to emerge and re-emerge as major agents of human diseases can ap pear almost limitless. Although current intervention strategies have demonstrated some success, rapid, innovative and effective solutions are needed to reduce the impact of new strains as they emerge. A FP7 program called: Preparedness, Prediction and Prevention of Emerging Zoonotic Viruses with Pandemic Potential using Multidisciplinary Approaches (PREDEMICS) is providing a platform for global analysis of the factors involved in crossing of the host species barrier and of the causal mechanisms leading to the emergence, maintenance and enzootic expansion of lyssaviruses, the agents of rabies, in animals and finally transmission to humans. Advanced knowledge on fundamental aspects of the viral reproductive and dissemination processes and on virus-host interactions will provide new potential approaches for interventions. Within this program, a three years post doctoral position is available immediately in the Unit Lyssavirus dynamics and host adaptation at the Institut Pasteur in Paris. Through the development and use of new molecular models and inference tools, you will contribute to the analysis of the genetic diversity and evolutionary dynamics of lyssaviruses within its various hosts. You will focus on the identification of viral genetic determinants involved in cross-species transmission from the dog to other carnivores. You will also investigate the pathogenesis of recombinant viruses obtained by reverse genetics exhibiting the different potential genetic signatures identified. Furthermore, using analyses in vitro and in vivo, you will characterize and evaluate viral and cellular factors that influence innate immunity and potential host switching.

Qualification The position is ideally suited for highly motivated and enthusiastic applicants with a PhD and a strong background in virology, molecular and cellular biology with an established publication record. Strong written and oral communications skills in english are required.

Additional Information Start date : immediately (duration 3 years) Gross salary: around 2,700 Euros per month Location : Paris, France Applicants should send their CV, a list of publication, a summary of their previous research activities (≤3 pages), a personnal statement and the names of three referees to the secretary of the unit, E-Mail : and use the following reference in the subject of the message: PostDoc PREDEMICS. Dead line for submission: May, 28th 2012 Website of the unit:


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