Institut Pasteur of Shanghai: two studies on HIV-1 infection and replication mechanisms


On December 30, 2015, the Journal of Virology published an advanced research work, entitled “Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells”, from Jian-Hua WANG's Lab, Institute Pasteur of Shanghai, Chinese Academy of Sciences. This work reveals a novel mechanism of HIV-1 mucosal infection (sexual transmission).


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On January 6th, 2016,Journal of Biological Chemistry published an other advanced research work from Jian-Hua WANG's Lab, entitled “HIV-1 Nef-associated factor 1 enhances viral production by interacting with CRM1 to promote nuclear export of unspliced HIV-1 gag mRNA”. This study reveals a novel function of cellular factor Naf1 in regulating HIV-1 production.