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How Zika virus induces congenital microcephaly

A team of researchers from ZIKAlliance discovers a specific mechanism of the infection.

Epidemiological studies show that in utero fetal infection with the Zika virus (ZIKV) may lead to microcephaly, an irreversible congenital malformation of the brain characterized by an incomplete development of the cerebral cortex. However, the mechanism of Zika virus-associated microcephaly remains unclear. An international team of researchers within the European consortium ZIKAlliance coordinated by Inserm in France, led by Dr. Laurent Nguyen (F.R.S.-F.N.R.S., GIGA Neuroscience, University of Liège) and Prof. Marc Lecuit (Institut Pasteur, Inserm, University Paris Descartes, Necker Children's Hospital, AP-HP), has identified a specific mechanism leading to this microcephaly. Their findings were published in Nature Neuroscience (December 2017).


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