Research

Researches

Roberto BRUZZONE, Co-Director

MD (Rome, Italy)

Co-Director of HKU-Pasteur Research Pole
Visiting Professor

Division of Public Health Laboratory Sciences

Contact Information
Tel: +852 2831 5522     Email: bruzzone@hku.hk
Address: 7/F Hong Kong Jockey Club Building for Interdisciplinary Research, 5 Sassoon Road, Hong Kong

Profile / Publications

Profile

Professor Roberto BRUZZONE was born in Italy and studied medicine at University “La Sapienza” in Rome. After work at the University of Geneva and Harvard Medical School, he joined Institut Pasteur in 1995. Roberto is a cell biologist widely recognized for his work on direct cell-cell communication through connexins and their associated human diseases. In October 2006, he was appointed as Visiting Professor in the Li Ka Shi Faculty of Medicine and served as the CEO of the HKU-Pasteur Research Centre, which has now become the HKU-Pasteur Research Pole of the Center of Influenza Research. Since coming to Hong Kong he has held positions of scientific and administrative leadership in teaching programs and major international networks to combat infectious diseases. He currently serves on the Executive Committee of the International Severe Acute Respiratory Infections Consortium (ISARIC) launched by the Wellcome Trust. He joined the School of Public Health in November 2012.

He is the author of over 100 publications with more than 7,000 citations. He was decorated in 2012 as Knight of the National Order of Merit in France for his contribution to the advancement of biomedical research in infectious diseases, and for his commitment to fostering exchanges in research and teaching between France and Hong Kong.

Top

Publications

  1. Tang D.J., Lam, Y.M., Siu Y.L., Lam C.H., Chu S.L., Peiris J.S., Buchy P., Nal B. and Bruzzone R. (2012) A single amino acid substitution in the 130-loop of the receptor-binding domain of H5N1 hemagglutinin is critical for efficient packaging into pseudotyped lentiviral particles. PLoS One7, e43596. (IF: 3.730;Times cited: 0)
  2. Jaume M., Yip M.S., Cheung C.Y., Leung H.L., Li P.H., Kien F., Dutry I., Escriou N., Altmeyer R., Nal B., Daëron M., Bruzzone R. and Peiris J.S. (2011) Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH- and cysteine protease-independent FcgR pathway. J. Virol. 85, 10582-10597. (IF: 5.076;Times cited: 2)
  3. Bruzzone R., Dubois-Dalcq M., Grau G.E., Griffin D.E. and Kristensson K. (2009) Infectious diseases of the nervous system and their impact in developing countries. PLoS Pathog. 5, e1000199. (IF: 8.136;times cited: 4)
  4. Kam Y.W., Okumura Y., Kido H., Ng L.F., Bruzzone R. and Altmeyer R. (2009) Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhance virus entry into human bronchial epithelial cells in vitro. PLoS One 4, e7870. (IF: 3.73; Times cited: 14)
  5. Siu Y.L., Teoh K.T., Lo J., Chan C., Kien F., Escriou N., Tsao S.W., Nicholls J.M., Altmeyer R., Peiris J.S., Bruzzone R. and Nal B. (2008) The M, E and N structural proteins of the SARS coronavirus are required for efficient assembly, trafficking and release of virus-like particles. J. Virol. 82, 11318-11330. (IF: 5.076; Times cited: 22)
  6. Bruzzone R., Barbe M.T., Jakob N.J. and Monyer H. (2005) Pharmacological properties of homomeric and heteromeric pannexin hemi-channels expressed in Xenopus oocytes. J. Neurochem. 92, 1033-1043. (IF: 3.973; Times cited: 190)
  7. Bruzzone R., Hormuzdi S.G., Barbe M.T., Herb A. and Monyer H. (2003) Pannexins, a family of gap junction proteins expressed in brain. Proc. Natl. Acad. Sci. USA 100, 13644-13649. (IF: 9.737; Times cited: 285)
  8. Baulac S., Huberfeld G., Gourfinkel-An I., Mitropoulou G., Beranger A., Prud’homme J-F., Baulac M., Brice A., Bruzzone R. and LeGuern E. (2001) First genetic evidence of GABAA receptor implication in epilepsy: a mutation in the g2 subunit gene (GABRG2). Nat. Genet. 28, 46-48. (IF: 35.209; Times cited: 442)
  9. Bruzzone R., White T.W. and Paul D.L. (1996) Connections with connexins: the molecular basis of direct intercellular signaling. Eur. J. Biochem. 238, 1-27. (IF: 4.250; Times cited: 956)
  10. White T.W., Paul D.L., Goodenough D.A. and Bruzzone R. (1995) Functional analysis of selective interactions among rodent connexins. Mol. Biol. Cell 6, 459-470. (IF: 4.803; Times cited: 183)

Top