Research

Researches

Publications

Year 2018

Zhang J, Su R, Jian X, An H, Jiang R, Mok CK

The D253N Mutation in the polymerase basic 2 gene in avian influenza (H9N2) virus contributes to the pathogenesis of the virus in mammalian hosts

PMID: 30569291 PMCID: PMC6335224 DOI: 10.1007/s12250-018-0072-8

Ng YP, Yip TF, Peiris JS, Ip NY, Lee SM

Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses

PMID: 29987581 DOI: 10.1007/s13365-018-0659-8

Ying Fan, Sumana Sanyal, Roberto Bruzzone

Breaking Bad: How Viruses Subvert the Cell Cycle

PMCID: PMC6252338 PMID: 30510918 doi: 10.3389/fcimb.2018.00396

Juliane Mayr, Kam Lau, Jimmy C. C. Lai, Ivan A. Gagarinov, Yun Shi, Sarah McAtamney, Renee W. Y. Chan, John Nicholls, Mark von Itzstein & Thomas Haselhorst

Unravelling the Role of O-glycans in Influenza A Virus Infection

PMID: 30401951 PMCID: PMC6219607 DOI: 10.1038/s41598-018-34175-3

Obiakor VC, Tun HM, Bridgman SL, Arrieta M, Kozyrskyj AL

The association between early life antibiotic use and allergic disease in young children: recent insights and their implications

PMID: 30198345 DOI: 10.1080/1744666X.2018.1521271

Li R, Yuan B, Xia X, Zhang S, Du Q, Yang C, Li N, Zhao J, Zhang Y, Zhang R, Feng Y, Jiao J, Peiris M, Zhong N, Mok CK, Yang Z

Tree shrew as a new animal model to study the pathogenesis of avian influenza

PMID: 30301950 PMCID: PMC6177411 DOI: 10.1038/s41426-018-0167-1

Ho NT, Li F, Lee-Sarwar KA, Tun HM, Brown BP, Pannaraj PS, Bender JM, Azad MB, Thompon AL, Weiss ST, Azcarate-Peril MA, Litonjua AA, Kozyrskyj AL, Jaspan HB, Aldrovandi GM, Kuhn L

Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations

PMID: 30301893 PMCID: PMC6177445 DOI: 10.1038/s41467-018-06473-x

Tun MH, Tun HM, Mahoney JJ, Konya TB, Guttman DS, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Sears MR, Brook JR, Lou W, Takaro TK, Scott JA, Kozyrskyj AL, CHILD Study Investigators

Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children

PMID: 30224442 PMCID: PMC6141245 DOI: 10.1503/cmaj.170809

Guan W, Wu NC, Lee HHY, Li Y, Jiang W, Shen L, Wu DC, Chen R, Zhong N, Wilson IA, Peiris M, Yang Z, Mok CK

Clinical correlations of transcriptional profile in patients infected with avian influenza H7N9 Virus

PMID: 29846612 PMCID: PMC6129114 DOI: 10.1093/infdis/jiy317

Babu TM, Perera R, Wu JT, Fitzgerald T, Nolan C, Cowling BJ, Krauss S, Treanor JT, Peiris Mc

Population serologic immunity to human and avian H2N2 viruses in the United States and Hong Kong for pandemic risk assessment

PMID: 29762672 PMCID: PMC6107991 DOI: 10.1093/infdis/jiy291

So RT, Perera RA, Oladipo JO, Chu DK, Kuranga SA, Chan KH, Lau EH, Cheng SM, Poon LL, Webby RJ, Peiris M

Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria

PMID: 30107872 PMCID: PMC6092911 DOI: 10.2807/1560-7917.ES.2018.23.32.1800175

Lai JC, Karunarathna HM, Wong HH, Peiris JS, Nicholls JN

Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding

PMID: 30866786 PMCID: PMC6455212 DOI: 10.1080/22221751.2019.1581034

Yip TF, Selim ASM, Lian I, Lee SM

Advancements in Host-Based Interventions for Influenza Treatment

PMID: 30042762 PMCID: PMC6048202 DOI: 10.3389/fimmu.2018.01547

Valkenburg SA, Li OTW, Li A, Bull M, Waldmann TA, Perera LP, Peiris M, Poon LLM

Protection by universal influenza vaccine is mediated by memory CD4 T cells

PMID: 29887326 DOI: 10.1016/j.vaccine.2018.06.007

Valkenburg SA, Leung NHL, Bull MB, Yan LM, Li APY, Poon LLM, Cowling BJ

The Hurdles From Bench to Bedside in the Realization and Implementation of a Universal Influenza Vaccine

PMID: 30013557 PMCID: PMC6036122 DOI: 10.3389/fimmu.2018.01479

Zhao X, Li R, Zhou Y, Xiao M, Ma C, Yang Z, Zeng S, Du Q, Yang C, Jiang H, Hu Y, Wang K, Mok CK, Sun P, Dong J, Cui W, Wang J, Tu Y, Yang Z, Hu W

Discovery of highly potent pinanamine-based inhibitors against amantadine- and oseltamivir-resistant influenza A viruses

PMID: 29799746 PMCID: PMC6496959 DOI: 10.1021/acs.jmedchem.8b00042

Zhang J, Lan Y, Li MY, Lamers MM, Fusade-Boyer M, Klemm E, Thiele C, Ashour J, Sanyal S

Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production

PMID: 29902443 DOI: 10.1016/j.chom.2018.05.005

Pombo JP, Sanyal S

Perturbation of Intracellular Cholesterol and Fatty Acid Homeostasis During Flavivirus Infections

PMID: 29915602 PMCID: PMC5994796 DOI: 10.3389/fimmu.2018.01276

Zhang T, Xiao M, Wong CK, Mok KC, Zhao X, Ti H, Shaw PC

Sheng Jiang San, a traditional multi-herb formulation, exerts anti-influenza effects in vitro and in vivo via neuraminidase inhibition and immune regulation

PMID: 29739459 PMCID: PMC5941478 DOI: 10.1186/s12906-018-2216-7

25. Yan LM, Li OTW, Poh CM, Perera RAPM, Valkenburg SA, Peiris M, Poon LLM

Combined use of live-attenuated and inactivated influenza vaccines to enhance heterosubtypic protection

Virology 525:73-82.

Clemens EB, van de Sandt C, Wong SS, Wakim LM, Valkenburg SA

Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine

PMID: 29587436 PMCID: PMC6027237 DOI: 10.3390/vaccines6020018

Clemens EB, van de Sandt C, Wong SS, Wakim LM, Valkenburg SA

Harnessing the power of T cells: The promising hope for a universal influenza vaccine.  Vaccines

PMID: 29587436 PMCID: PMC6027237 DOI: 10.3390/vaccines6020018

Chu DKW, Hui KPY, Perera RAPM, Miguel E, Niemeyer D, Zhao J, Channappanavar R, Dudas G, Oladipo JO, Traoré A, Fassi-Fihri O, Ali A, Demissié GF, Muth D, Chan MCW, Nicholls JM, Meyerholz DK, Kuranga SA, Mamo G, Zhou Z, So RTY, Hemida MG,Webby RJ, Roger F, Rambaut A, Poon LLM, Perlman S, Drosten C, Chevalier V, Peiris M

MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity

PMID: 29507189 PMCID: PMC5866576 DOI: 10.1073/pnas.1718769115

Lee SM, Yip TF, Yan S, Jin DY, Wei HL, Guo RT, Peiris JSM

Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10

Front Immunol. 2018 Mar 16;9:516. doi: 10.3389/fimmu.2018.00516. eCollection 2018

Tam YH, Valkenburg SA, Perera RAPM, Wong JHF, Fang VJ, Ng TWY, Kwong ASK, Tsui WWS, Ip DKM, Poon LLM, Chau CKV, Barr IG, Peiris JSM, Cowling BJ

Immune Responses to Twice-Annual Influenza Vaccination in Older Adults in Hong Kong

PMID: 29069368 DOI: 10.1093/cid/cix900

Zhang N, Bao YJ, Tong AH, Zuyderduyn S, Bader GD, Malik Peiris JS, Lok S, Lee SM

Whole transcriptome analysis reveals differential gene expression profile reflecting macrophage polarization in response to influenza A H5N1 virus infection

PMID: 29475453 DOI: 10.1186/s12920-018-0335-0

Nguyen THO, Sant S, Bird NL, Grant EJ, Clemens EB, Koutsakos M, Valkenburg SA, Gras S, Lappas M, Jaworowski A, Crowe J, Loh L, Kedzierska K

Perturbed CD8+ T cell immunity across universal influenza epitopes in the elderly

PMID: 28928269 DOI: 10.1189/jlb.5MA0517-207R

Huang J, Liang W, Chen S, Zhu Y, Chen H, Mok CK, Zhou Y

Serum cytokine profiles in patients with dengue fever at the acute infection phase

PMID: 29651328 PMCID: PMC5831957 DOI: 10.1155/2018/8403937

Mak GCK, Kwan MY, Mok CK, Lo JYC, Peiris M, Leung CW

Influenza A(H5N1) virus infection in a child with encephalitis complicated by obstructive hydrocephalus

PMID: 29020163 PMCID: PMC5850530 DOI: 10.1093/cid/cix707

Herfst S, Mok CKP, van den Brand JMA, van der Vliet S, Rosu ME, Spronken MI, Yang Z, de Meulder D, Lexmond P, Bestebroer TM, Peiris JSM, Fouchier RAM, Richard M.

Human Clade 2.3.4.4 A/H5N6 Influenza Virus Lacks Mammalian Adaptation Markers and Does Not Transmit via the Airborne Route between Ferrets

mSphere. 2018 Jan 3;3(1). pii: e00405-17. doi: 10.1128 mSphere.00405-17