Research

Researches

10 Feb 2020

Assessment of enhanced influenza vaccination finds that FluAd conveys an advantage in mice and older adults

We are very happy to announce the publication of the paper Assessment of enhanced influenza vaccination finds that FluAd conveys an advantage in mice and older adults by Sophie Valkenburg and her team: Niloufar Kavian, postdoctora fellow, Asmaa Hachim, research assistant, Athena PY Li, PhD student and Carolyn A Cohen, PhD student!

They published it in Clinical & Translational Immunology with Leo Poon, Benjamin Cowling and fellow colleagues from the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong.

In this randomised clinical trial, we showed that enhanced influenza vaccines boost antibody quality in older adults, and showed a particular advantage of adjuvanted vaccines for long‐term high‐avidity and haemagglutinin‐stalk antibodies. This action translated to an increased protection by the same adjuvanted vaccines in mice for reduced viral loads and inflammation as a result of early and enhanced B‐cell recruitment and activation for antibody production. Sophie Valkenburg

>>> Assessment of enhanced influenza vaccination finds that FluAd conveys an advantage in mice and older adults.

Kavian N, Hachim A, Li AP, Cohen CA, Chin AW, Poon LL, Fang VJ, Leung NH, Cowling BJ, Valkenburg SA.

PMID: 32025302 PMCID: PMC6997034 DOI: 10.1002/cti2.1107