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15 May 2019

[Call for Application] 9th HKU-Pasteur Cell Biology Course on Proteomics

We had a great time last year, and we are ready for the next round! Applications for the 9th HKU-Pasteur Cell Biology Course, focusing this year on Proteomics, are now open:

 Application form / Tips for Application 

Date: October 27 - November 2, 2019
Deadline for Application: August 9, 2019
Venue: HKU-Pasteur Research Pole
 

With the advent of more sophisticated technology and instrumentation in mass spectrometry, a strong interest has emerged to assess and interrogate biology at the level of protein networks, along with the more conventional genomic and transcriptomic approaches. Both systems-wide as well as targeted proteomic strategies have proved critical for generating hypotheses in various cellular perturbations. 

The 9th HKU-Pasteur Cell Biology Course will focus on proteomics based approaches to probe the cell biology underlying human diseases. The lectures and workshops will present an advanced overview of how the integration of conventional “omics“ approaches with that of proteomic analyses leads to deeper understanding of biological processes and signaling pathways.

Course directors: Roberto BRUZZONE (Hong Kong); Philippe CHAVRIER (France); Sumana SANYAL (Hong Kong); George TSAO (Hong Kong); Chiara ZURZOLO (France)
 
Faculty: Oreste ACUTO (United Kingdom); Roberto BRUZZONE (Hong Kong); Francis IMPENS (Belgium); Benedikt KESSLER (United Kingdom); Daniel KOLARICH (Australia); Yun LAN (Hong Kong); Fan LIU (Germany); Liliana RADOSHEVICH (USA); Sumana SANYAL (Hong Kong); Florian SCHMIDT (Germany); Rakesh SHARMA (Hong Kong); George TSAO (Hong Kong); Michael WEEKES (United Kingdom)
 
Open to postgraduate students, MD, DVM, postdoctoral fellows and young scientists from Hong Kong and overseas. The course (MMPH6174) is included in the coursework curriculum for research postgraduate studies of the University of Hong Kong.
 
Registration fees (HKD 1,500) include accommodation (on sharing twin basis for overseas participants) and food (lunch and coffee breaks).
 
 
 
A limited number of travel grants will be awarded.
 
Please return the completed form, including 1-2 letters of recommendation to hku-pasteur@hku.hk.
 

01 Apr 2019

[Call for application] Advanced Imaging: Deep Learning in Imaging and Cell Biology

Applications are open for the Croucher Summer Course on Advanced Imaging: Deep Learning in Imaging and Cell Biology organized by HKU-Pasteur from 25th to 30th of August, 2019. 

 
Date: August 25-30, 2019
Application deadline: 31st May 2019
Venue: LKS Faculty of Medicine, The University of Hong Kong
 
 
Imaging lies at the heart of the investigation of biological processes from the molecular level to entire organisms. While steady advances in microscopy technology are opening new windows into the inner workings of the biological systems, imaging has hard limits stemming from optics of the microscope, chemistry of fluorophores and the necessity to keep the imaged sample alive. Recently, deep learning has emerged as a powerful approach to making trade-offs between imaging speed, image quality and sample health, that make many previously inaccessible imaging scenarios possible. It has been shown that by incorporating deep learning driven image restoration into imaging pipelines, it is possible to image biological specimen with dramatically reduced laser power, achieve isotropic resolution from under-sampled 3D volumes and even resolve structures below the diffraction limit faster.
 
This course will focus on the application of leading deep learning framework for microscopy image restoration, the Content Aware Image Restoration (CARE), to various biological image restoration tasks. The power of deep learning in microscopy will be demonstrated using open source tools such as Fiji, KNIME and Jupyter notebooks that make the advanced technologies accessible to anyone.
 
Besides the in-depth practical experience with CARE, the participants will learn about alternative computational approaches to super-resolution microscopy and about handling of big microscopy image datasets. Finally, the impact of computational techniques on biological imaging will be demonstrated on frontier biological applications spanning across scales of biological complexity from molecular (Cryo-EM), to subcellular (nuclear organization) to organismal (tissue mechanics) levels.
 
During the practical part of the course the students will learn how to:
 
- Collect appropriate training data on the provided samples using diverse microscopy hardware.
- Train CARE networks on state-of-the-art as well as commodity computer hardware.
- Apply CARE networks to restore the data acquired during the course.
- Learn how to evaluate the CARE results and avoid potential artefacts.
 
Course directors:
Prof Roberto BRUZZONE, HKU-Pasteur Research Pole, The University of Hong Kong, HKSAR 
Dr Musa MHLANGA, University of Cape Town, South Africa
Prof George TSAO, School of Biomedical Sciences, The University of Hong Kong, HKSAR
 
Faculty:
Sian Culley, MRC Laboratory for Molecular Cell Biology, University College London, UK
Florian Jug, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Musa Mhlanga, University of Cape Town, South Africa
Gaia Pigino, Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany
Pavel Tomancak, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Martin Weigert, Center for Systems Biology Dresden, Dresden, Germany
Marino Zerial, Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany
Christophe Zimmer, Institut Pasteur, France
 

Registration Fee: HK$ 3000

Registration Deadline: May 31, 2019

Participants’ profile: Postgraduate Students, Post-docs and Junior Group Leaders.

Travel fellowship: Up to 5 fellowships will be awarded to the best applicants.
 
Please contact course secretary if you have enquiries at corefac@hku.hk.
 
 

 

15 May 2019

15th HKU-Pasteur Virology Course: the program is available!

The program for the 15th HKU-Pasteur Virology Course on Coronaviruses that will be held from July 7 to 13, 2019, is now available!

>>> Download the program <<< 

Most endemic coronaviruses (CoV) cause mild respiratory and intestinal infections in animals and humans. The identification of two novel and highly pathogenic coronaviruses as the cause of SARS and MERS outbreaks has illustrated the risks associated with zoonotic infections from this family of viruses. This course will review our current understanding and knowledge gaps, with special emphasis on the origin, evolution, transmissibility, molecular biology, epidemiological and clinical features of the highly pathogenic SARS-CoV and MERS-CoV. Practical workshops will challenge participants to design experimental strategies to mitigate the impact of CoV infections.

Course directors: Roberto BRUZZONE (Hong Kong) ; Chris MOK (Hong Kong) ; Malik PEIRIS (Hong Kong) ; Noel TORDO (Guinea) 

Faculty: Marcel BOKELMANN (Germany) ; Roberto BRUZZONE (Hong Kong) ; Emmie DE WIT (USA) ; Bart HAAGMANS (Netherlands) ; Yae-Jean KIM (Korea) ; Raven KOK (Hong Kong) ; Mart LAMERS (Netherlands) ; Eve MIGUEL (France) ; Jean MILLET (France) ; Chris MOK (Hong Kong) ; Malik PEIRIS (Hong Kong) ; Peter ROTTIER (Netherlands) ; Zhengli SHI (China) ; Amy SIMS (USA) ; Noel TORDO (Guinea) ; Maria VAN KERKHOVE (Switzerland) ; Patrick WOO (Hong Kong) ; Nicholas WU (USA) ; Jincun ZHAO (USA) 

25 Apr 2019

[Registration] The Institut Pasteur Epigenetics MOOC is now open for registration!

The new Institut Pasteur MOOC on Epigenetics is now open for registration. The courses will start on July 8th, 2019:

The life of a multicellular organism, including us, starts as a single cell with a unique genome. However, during development all the cells of our body inherit the same genome despite being so different among each other. This implies that additional information must be inherited in each different cell type to instruct their fate. Moreover, because during our existence the genome does not change, our life experience cannot be transmitted to the next generation by the genome.
 
Based on several observations in different model organisms in recent years, many biologists have been questioning the dogmatic view of the genome as being the only source of information transmitted through cell divisions and across generations. The discovery and the characterization of new types of information transmitted along with the genome is what we usually call epigenetics. The capability of transmitting information across individuals beyond their genes is quite revolutionary in biology and this is the reason why the field of epigenetics is still very controversial and deeply investigated by many scientists around the world. Nonetheless, extensive research in the past years helped to reveal how our genome is organized in the nucleus and to characterize the different types of transient chemical modifications that regulate the activity of the genome in our cells. These chemical modifications that surround the genome, called epigenetic modifications, constitute one of the fundamental bases of the epigenetic process. In addition, other types of molecules, such as RNA, serve to transmit heritable information across cell divisions. Drawing on this knowledge, we are starting to appreciate how epigenetic information can have an influence on the development of multicellular organisms and how it can impact human health. Thus, the full understanding of the mechanisms regulating epigenetic processes will contribute to expand our notion of genetics, heritability, and diseases.
 
This course aims to provide a basic fundamental knowledge of what is considered to be epigenetics and wants to illustrate well characterized examples of epigenetic phenomena in many different model organisms. In addition, we will explain in detail the molecules that participate in the epigenetic inheritance and their mechanisms of action. Furthermore, we will discuss the implication of epigenetics in development, and how environmental experiences can change our life and the life of our progenies through epigenetic mechanisms. Finally, we will describe examples of diseases that are influenced by epigenetic mechanisms. 
 
 
The MOOC is in English with French and English subtitles, it is free of charge, takes on average 2.5 hours/week and offers a certificate after passing the final exam. It encompasses voluntary tests for checking your self-paced learning progress.
 
This course has been organized by Dr. Germano Cecere, head of the Mechanisms of Epigenetic Inheritance lab at Institut Pasteur Paris. It includes 20 talks from leading scientists in the field,  that will cover state-of-the-art concepts from basic to medical research. It is suited for medical doctors, scientists, post-docs, all kind of students in natural sciences and medicine, health care workers and anyone interested in the field.
 
List of speakers:
Slimane Ait-Si-Ali (Université Paris-Diderot)          
Benoit Arcangioli (Institut Pasteur) 
Paola Arimondo (Institut Pasteur)                            
Valentina Boeva (Inserm, Paris) 
Matthieu Boulard (EMBL, Rome)                            
Giacomo Cavalli (IGH, Montpellier) 
Vincent Colot (ENS Paris)                                        
Eugene Gladyshev (Institut Pasteur) 
Maxime Greenberg (Institut Curie)                          
Thomas Gregor (Institut Pasteur) 
Mélanie Hamon (Institut Pasteur)                            
Michelle Holland (King's College London)
Nicola Iovino (Max Planck Institute, Freiburg)        
Francesca Merlin (Sorbonne U, Paris) 
Pablo Navarro-Gil (Institut Pasteur)                        
Lluis Quintana-Murci (Institut Pasteur)
Claire Rougeulle (Université Paris-Diderot)            
Ritwick Sawarkar (Max Planck Institute, Freiburg)
Jonathan Weitzman (Université Paris-Diderot)
 

08 Apr 2019

[NEW DEADLINE] 15th HKU-Pasteur Virology Course: Coronaviruses

Applications are open for the 15th HKU-Pasteur Virology Course on Coronaviruses that will be held from July 7 to 13, 2019 in Hong Kong: 

Date: July 7 - 13, 2019

APPLICATION CLOSED

Application form / Tips for application

Most endemic coronaviruses (CoV) cause mild respiratory and intestinal infections in animals and humans. The identification of two novel and highly pathogenic coronaviruses as the cause of SARS and MERS outbreaks has illustrated the risks associated with zoonotic infections from this family of viruses. This course will review our current understanding and knowledge gaps, with special emphasis on the origin, evolution, transmissibility, molecular biology, epidemiological and clinical features of the highly pathogenic SARS-CoV and MERS-CoV. Practical workshops will challenge participants to design experimental strategies to mitigate the impact of CoV infections. 

Course directors: Roberto BRUZZONE (Hong Kong) ; Chris MOK (Hong Kong) ; Malik PEIRIS (Hong Kong) ; Noel TORDO (Guinea) 

Faculty: Marcel BOKELMANN (Germany) ; Roberto BRUZZONE (Hong Kong) ; Emmie DE WIT (USA) ; Bart HAAGMANS (Netherlands) ; Yae-Jean KIM (Korea) ; Raven KOK (Hong Kong) ; Mart LAMERS (Netherlands) ; Eve MIGUEL (France) ; Jean MILLET (France) ; Chris MOK (Hong Kong) ; Malik PEIRIS (Hong Kong) ; Peter ROTTIER (Netherlands) ; Zhengli SHI (China) ; Amy SIMS (USA) ; Noel TORDO (Guinea) ; Maria VAN KERKHOVE (Switzerland) ; Patrick WOO (Hong Kong) ; Nicholas WU (USA) ; Jincun ZHAO (USA) 

Open to postgraduate students, MD, DVM, postdoctoral fellows and young scientists from Hong Kong and overseas. 
 
Registration fees (HKD 1,500) include accommodation (on sharing twin basis for overseas participants) and food (lunch and coffee breaks). Please return the completed form, including 1-2 letters of recommendation, to hku-pasteur@hku.hk.
 
 
The course (MMPH6171) is included in the coursework curriculum for research postgraduate studies of the University of Hong Kong.
 

01 Apr 2019

Registrations for the Institut Pasteur International Course on Antibiotics and Resistance (ICARe) 2019 are open

The Institut Pasteur International Course on Antibiotics and Resistance (ICARe) will be held from October 19th to 27th in the wonderful city of Annecy, France.
 
The emergence and spread of bacteria resistant to many drug classes seriously threaten all branches of modern medicine. There is currently no course providing advanced instruction on antibiotics and resistance. The specific goal of ICARe is to bring leaders in academics and industry together with trained scientists at the dawn of their careers. Cutting-edge approaches for the study of resistance and antibiotic discovery will be examined.
 
 
Deadline for application: May 17, 2019 
 
Objective:
The faculty, composed of 40 internationally recognized scientists and physicians who have made important contributions to antibiotic development, infectious diseases, and resistance management, will be in residence for a minimum of 2 days for informal interactions. Graduates will emerge with a state- of-the-art understanding of existing antibiotics (modes of action, mechanisms of resistance), approaches for mining chemical space, advancing hits to leads, the application of nucleic acid- based technologies and bioinformatics for antibiotic discovery and resistance detection.The course aims to build an international cadre of collaborative, well networked, and highly trained specialists.
 
Director: Patrice Courvalin
Scientific advisors: Michael Gilmore and Gerry Wright
 
Scientific committee:
C. Arias (Univ. of Texas, USA), G. Challis (Univ. of Warwick, UK), T. Dougherty (Harvard Medical School, USA), S. Lahiri (Macrolide Pharmaceuticals, USA), S. Lory (Harvard Medical School, USA), A. Myers (Harvard Univ., USA), S. Projan (MedImmune, USA), H.-G. Sahl (Univ. of Bonn, Germany), M.-W. Tan (Genentech, USA).
 
Audience:
ICARe is designed for assistant professors, new industry scientists, MDs, and postdoctoral research associates, as well as members from developing areas contending with the practical challenge of managing the antibiotic resistance problem with limited resources.
 
Attendees: 40 students
 
 

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