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02 Feb 2016

Christian Bréchot takes part in the World Economic Forum in Davos

On Thursday, January 21, 2016, Christian Bréchot, President of Institut Pasteur, attended the World Economic Forum (WEF) for the first time. He was invited to contribute to the ongoing discussion on innovative methods for the development and distribution of vaccines to combat emerging diseases.

This initiative followed on from a series of reports containing recommendations on how we can be better prepared to deal with future epidemic outbreaks of highly dangerous pathogens. It is also part of the response to the call for ideas for global action launched by WHO.

Leaders of large research institutions, among them the NIH and the Institut Pasteur, the major financial supporters of research, such as the Wellcome trust, and industry suggested that a partnership should be set up to boost coordination and cooperation among key players in R&D so that new vaccines can be developed for high priority pathogens (particularly those identified by WHO) and other pathogens likely to cause outbreaks in the future.

The WEF is a non-profit foundation that was set up in 1971 by Klaus M. Schwab, an economics professor based in Switzerland. It is known for its Annual Meeting in the Swiss town of Davos, attended by company directors, international political leaders, representatives of academia and NGOs, intellectuals, and journalists.

Topics on the agenda include the most pressing issues facing the planet, particularly in the areas of health, the environment, international conflicts and poverty. The Forum also publishes economic reports and involves its members in a range of initiatives associated with specific industry sectors.

The theme of this year's 46th WEF Annual Meeting was "Navigating the Fourth Industrial Revolution". Discussions focused on the best way to respond to the rapid technological developments that are disrupting virtually every industry in the global economy.

From Institut Pasteur (January 29, 2016)

01 Feb 2016

Call for Traineeship Grants Calmette & Yersin

The Department of International Affairs of the Institut Pasteur launches the call for Traineeship Grants, Calmette and Yersin Programme. These grants, funded by the Department of International Affairs, are designed to facilitate mobility within the Institut Pasteur International Network (RIIP) and to promote and facilitate traineeships at Institut Pasteur in Paris or in a RIIP member institute for scientists (students, researchers and technicians) from the Institut Pasteur and from the RIIP.

To find a traineeship within the RIIP, you can consult the RIIP DATABASE, a unique reference base accessible by institutions, scientific staff and projects: http://databaseriip.pasteur.fr

Application deadline: April 15, 2016.

Online applications exclusively: http://bourses.pasteur-international.org/public.aspx

You will find all information on this call on the website: http://www.pasteur.fr/en/international/international-network-courses/fellowships/traineeship-grants

Contact:  
Eliane Coëffier
eliane.coeffier@pasteur.fr  

and copy bourses-international@pasteur.fr

25 Jan 2016

International call for candidates to head 4-year group within the Institut Pasteur International Network

Agence Universitaire de la Francophonie (AUF) and Institut Pasteur are jointly launching an international call for applications for future leaders of 4-Year Groups (G4) within the Institut Pasteur International Network (RIIP), following the signing of a partnership agreement on 26 November 2015.    

Closing date for applications: 31 March 2016   

Promoting new talents

AUF and Institut Pasteur wish to strengthen their collaborations in the areas of research, training and teaching, especially in Sub-Saharan Africa and Southeast Asia. They are launching a joint international call for applications from young researchers in the life sciences who wish to create a research group within RIIP in these two regions (Cameroon, Côte d’Ivoire, Guinea, Madagascar, Niger, Senegal, the Central African Republic, Cambodia, China, Korea, Laos and Vietnam).   

Criteria for the call for applications 

The young scientist leading the group must propose an innovative and ambitious international research programme in infectious, tropical or neglected diseases.  His/her multidisciplinary project should be of an excellent standard in microbiology, virology, immunology, genetics, epidemiology or entomology, and should involve national and international member universities of AUF in order to strengthen the latter in their research and training roles. This involvement will take the form of training Master’s and Doctoral students hosted by the G4 and/or participating in research conducted by lecturer-researchers from the partner university or universities. Wherever possible, research subjects will be defined in collaboration with the university teams.

More details, application and contact information on Institut Pasteur website.

Agence Universitaire de la Francophonie (AUF) and Institut Pasteur are jointly launching an international call for applications for future leaders of 4-Year Groups (G4) within the Institut Pasteur International Network (RIIP), following the signing of a partnership agreement on 26 November 2015.

 

Closing date for applications: 31 March 2016

 

Promoting new talent

AUF and Institut Pasteur wish to strengthen their collaborations in the areas of research, training and teaching, especially in Sub-Saharan Africa and Southeast Asia. They are launching a joint international call for applications from young researchers in the life sciences who wish to create a research group within RIIP in these two regions (Cameroon, Côte d’Ivoire, Guinea, Madagascar, Niger, Senegal, the Central African Republic, Cambodia, China, Korea, Laos and Vietnam).

 

Criteria for the call for applications

The young scientist leading the group must propose an innovative and ambitious international research programme in infectious, tropical or neglected diseases.

His/her multidisciplinary project should be of an excellent standard in microbiology, virology, immunology, genetics, epidemiology or entomology, and should involve national and international member universities of AUF in order to strengthen the latter in their research and training roles. This involvement will take the form of training Master’s and Doctoral students hosted by the G4 and/or participating in research conducted by lecturer-researchers from the partner university or universities. Wherever possible, research subjects will be defined in collaboration with the university teams.

- See more at: http://www.pasteur.fr/en/international/international-network-courses/4-year-group#sthash.tHvJbYNC.dpuf

12 Jan 2016

Institut Pasteur of Shanghai: two studies on HIV-1 infection and replication mechanisms

On December 30, 2015, the Journal of Virology published an advanced research work, entitled “Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells”, from Jian-Hua WANG's Lab, Institute Pasteur of Shanghai, Chinese Academy of Sciences. This work reveals a novel mechanism of HIV-1 mucosal infection (sexual transmission).

Please visit IPS website for more information.

On January 6th, 2016,Journal of Biological Chemistry published an other advanced research work from Jian-Hua WANG's Lab, entitled “HIV-1 Nef-associated factor 1 enhances viral production by interacting with CRM1 to promote nuclear export of unspliced HIV-1 gag mRNA”. This study reveals a novel function of cellular factor Naf1 in regulating HIV-1 production.

Please visit IPS website for more information.

11 Jan 2016

ZIKA INFECTION: a collaborative website for research on Zika virus

Oswaldo Cruz Foundation (Fiocruz)
International Severe Acute Respiratory and emerging Infection Consortium (ISARIC)
The Global Health Network
World Health Organization (WHO)
Institut Pasteur International Network
and al.
have launched a collaborative website on Zika virus infection: zicainfection

The aim of this website is to provide a platform for sharing and developing research priorities, protocols, data capture systems alongside the latest epidemiology and clinical management information about Zika infection.

11 Jan 2016

Researchers of the Institut Pasteur in French Guiana publish the first complete viral genome sequence of the Zika virus circulating in the Americas

The Institut Pasteur in French Guiana has just sequenced the complete viral genome of the Zika virus that causes an unprecedented outbreak in the tropical area of the American continent. Analyses of this viral sequence, published in The Lancet, show that there is a quasi-total homology with the strains responsible for epidemics in the Pacific region in 2013 and 2014.

Last November, the Virology laboratory in the Institut Pasteur in French Guiana (National reference centre for Arboviruses in the French Antilles and Guiana) confirmed the first five cases of indigenous Zika virus infection in Suriname. From one of these samples, researchers from the Institut Pasteur in French Guiana sequenced the complete viral genome of the strain. Analyses of this viral sequence, published in The Lancet*, show that it belongs to the Asian lineage of Zika virus and reveal more than 99% homology to the strain responsible for the outbreak in French Polynesia in 2013.

"Until now, only few complete viral sequences and none from the strain currently circulating in the Americas were available. Obtaining the complete viral genome sequence is a major base to better understand the virus evolution." says Dr. Dominique Rousset, in charge of the Virology laboratory and the National reference centre for Arboviruses.

In May 2015, first cases of Zika virus infection were confirmed in Brazil. Today, the country faces an unprecedented outbreak: 440,000 to 1,300,000 suspected cases according to Brazilian Health authorities. The virus has also rapidly spread and affects 10 countries in the tropical area of the American continent and Caribbean. Whereas the infection was considered as benign until recently, the epidemics of 2013-2014 in the Pacific region had occurred along with severe neurological syndromes (as Guillain-Barré syndrome) and congenital brain malformations. In Brazil, the significant increase in microcephaly in newborns whose mothers were infected during pregnancy led the government to declare a public health emergency in December 2015.

"Are these anomalies only due to Zika virus, or are they also caused by the co-circulation of other infectious pathogens or other factors? Interdisciplinary research projects have to be set up to answer these questions. We are already working to better understand the virus and its evolution, which requires a reinforcement of diagnostic tools in particular." says Dr. Dominique Rousset.

17 cases of Zika virus infection have been confirmed in French Guiana, and 3 in Martinique. The Institut Pasteur in French Guiana is strongly mobilized in epidemiological surveillance, partnering with Health authorities and the Institut Pasteur International Network (IPIN). "We are committed in supporting anti-vectorial measures through the monitoring of insecticide resistance in association with the Regional Health Agency. Researches on vector competence in Aedes aegypti for different arboviruses including Zika virus are carried out in the Vectopole" says Dr. Isabelle Dusfour, entomologist at the Institut Pasteur in French Guiana.

Furthermore, a team of 4 researchers from the Institut Pasteur in Dakar (Senegal) directed by Dr. Amadou Sall have joined Brazilian scientists to face the outbreak (collaboration with the University of São Paulo).

 

[*]: Enfissi et al., Zika virus genome from the Americas, The Lancet, 7 January 2016.

 

From www.pasteur.fr

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