19 Aug 2016
Scientists from the Institut Pasteur Paris led by Roland Brosch and Laleh Majlessi (Unit for Integrated Mycobacterial Pathogenomics), working in collaboration with a team from Italy (Department of Biology, University of Pisa), have published the results of their research into the action mechanisms of a promising experimental tuberculosis (TB) vaccine in the journal PLOS Pathogens. BCG, the only currently approved TB vaccine, has been around for almost a century, but it is only partially effective and the protection it offers fades over time. Given the current emergence of adult TB cases in conjunction with the HIV epidemic and the rise in multidrug-resistant TB strains, the development of a new, more effective vaccine is a global health priority. This research was conducted in connection with the TBVAC2020 European consortium.
CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection, PLoS Pathog. July 28, 2016 DOI : 10.1371/journal.ppat.1005770.
Read the full story on Institut Pasteur website.
18 Aug 2016
Institut Pasteur International Network Symposium: “From basic science to biomarkers & tools in global health”, Paris, November 29-December 2, 2016
A unique international scientific symposium on biomarkers open to all the scientific community
The 2016 edition of the Scientific Symposium of the Institut Pasteur International Network will cover every aspects of research including basic, clinical and operational science, necessary to identify, validate and develop new biomarkers in human health.
All scientists, clinicians and public health experts from both communicable and non-communicable diseases fields, belonging or not to the Institut Pasteur International Network are welcome to attend as well as civil society representatives, government & international organizations officials and industrial partners.
Building on the success of the last two editions, the Institut Pasteur International Network is confident that this symposium will again establish a high-level forum for multidisciplinary dialogue and exchanges between all stakeholders involved in Global Health/One Health and thus be an opportunity to create fruitful synergies and promote international collaborations that will source of hope for the world health.
To visit the official website and access to online registration, please click here or on the poster below.
26 Jul 2016
Elie METCHNIKOFF: From embryology to aging, from phagocytes to microbiota
Paris, September 26, 2016
This year, we celebrate one century of the many legacies of the great scientist Elie Metchnikoff. The Institut Pasteur organizes a one-day symposium that will illustrate the impact of his work on modern biology. The Institut is also displaying an exhibition that presents the life and multiple achievements of Metchnikoff, who worked here for 28 years.
Metchnikoff is considered the father of phagocytes, innate cellular immunity, probiotics and gerontology. His initial work as a comparative embryologist led him to be one of the founding fathers of immunology, and develop a new understanding of physiology and pathology. As an illustration of his boundless curiosity, his team investigated inflammation in guinea pigs, rats and frogs, infectious diseases in monkeys, caimans and geese, and aging in parrots, rabbits, dogs and humans. He then explored the gut microbiota of these animals and generated germ-free organisms. His later studies led him to propose that fermented milk delays the deleterious and pro-aging effects of toxic compounds released by putrefactive gut bacteria. Finally, he was also a philosopher, and ventured into writing essays on natural harmony, human disharmony, pessimism and, in the face of it all, optimism. In all these fields, Metchnikoff has been a visionary, publishing more than 200 papers in the Annales de l’Institut Pasteur. He has also been a remarkable team leader and mentor, supervising more than 100 young trainees and collaborators.
This symposium will begin with an opening talk to remind us of the life and many achievements of Elie Metchnikoff. The sessions will then illustrate the four major scientific fields pioneered by Metchnikoff - embryology, macrophages and immunity, microbiota, and aging. The speakers will illustrate these periods through their own work, and project their modern visions of Metchnikoff’s legacy. Finally, a closing talk will reflect on the visions of Metchnikoff for the future of biology.
For registration, program and more information, please click on the poster below:
12 Jul 2016
Dr Keiji Fukuda, Special Representative for Antimicrobial Resistance and World Health Organization Assistant Director-General will give a seminar at the Public Health Research Centre (PHRC) of the University of Hong Kong entitled The Nature of Present and Future Global Health Challenges, on Friday July 22, 2016.
Antimicrobial resistance (AMR) can be considered indicative of what global public health challenges in the modern era have become. The core technical issue is that a combination of microbial genetics and widespread use of antimicrobial medicines in human health and agricultural sectors is driving increasingly higher levels of resistance to such medicines among a wide range of pathogens. One immediate consequences is an estimated 700,000 deaths per year associated with such resistance, and projections of up to 10 million death per year by 2050. This seminar will look at the underlying factors contributing to the widespread use and overuse of such antimicrobial medicines, the combined impact of this issue, the breadth of groups and sectors needed to achieve an effective and sustained response to this growing global health security issue, the major challenges of AMR and the options for continued momentum after the high-level meeting at the United Nations General Assembly in September 2016.
Date: July 22, 2016 (Friday)
Time: 11:30 to 13:00 (sandwich lunch from 11:30 to 11:45; seminar begins at 11:45)
Venue: Mrs Chen Yang Foo Oi Telemedicine Centre (MTC), 2/F, William MW Mong Block, LKS Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong
Online registration is available here.
Please register on or before noon of July 19, 2016 (Tuesday). Sandwiches will be provided to registered participants of the seminar.
24 Jun 2016
International Call for Applications for a Leader of 4-year research group within the Institut Pasteur in Côte d’Ivoire
Closing date for applications: September 30th, 2016
The Department of International Affairs of the Institut Pasteur is launching an international call for applications for future leader of 4-Year Groups (G4) within the Institut Pasteur in Côte d’Ivoire.
The candidate will be appointed head of a research group for 4 years and will receive start-up funding that includes his/her own salary and potentially that of engineers, technicians and doctoral students, as well as basic laboratory equipment and an operating budget. The candidate should subsequently obtain fresh funding to maintain his/her group on the longer term.
Chronic hepatitis, cirrhosis and primary liver cancer (mostly hepatocellular carcinomas), related to chronic Hepatitis B and C infections or other etiological factors, represent a major public health problem in African countries at large and in Côte d'Ivoire in particular. Biomarkers that might reliably indicate the stage and predict the evolution of the liver disease would be of major value for the implementation of the most appropriate and efficient measures for patients' management.
The Institut Pasteur in Côte d’Ivoire is a national institute whose missions include public health activities, teaching and research. It is part of the Institut Pasteur International Network that comprises 33 institutes worldwide.
Applications are completed exclusively online: http://g4.pasteur-international.org
Contact: Eliane Coëffier
For more information see the webpage: http://www.pasteur.fr/en/international/international-network-courses/4-year-group
24 Jun 2016
Félix Rey, Head of the Structural Virology Laboratory at the Institut Pasteur in Paris and his co-workers from the Institut Pasteur and the French National Centre for Scientific Research, in collaboration with Imperial College London and the University of Vienna, Austria, have identified antibodies that can efficiently neutralize both the dengue virus and the Zika virus. The description of the binding site for these antibodies on the viral envelope, identical for both viruses, could lead to the development of a universal vaccine that offers simultaneous protection against dengue and Zika virus disease. These results were published in the journal Nature on June 23, 2016.
3D structure of the Zika virus envelope protein (red, yellow and blue) in complex with the neutralizing antibody (in green and white). © Institut Pasteur
Barba-Spaeth G, Dejnirattisai W, Rouvinski A, Vaney MC, Medits I, Sharma A, Simon-Lorière E, Sakuntabhai A, Cao-Lormeau VM, Haouz A, England P, Stiasny K, Mongkolsapaya J, Heinz FX, Screaton GR, Rey FA
Nature (2016) doi:10.1038/nature18938
Read the full story on the Institut Pasteur website.