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HKU-PRP News

04 Feb 2016

Read Roberto Bruzzone’s interview in The Standard about research and education opportunities in France

In the issue of February 2, 2016, The Standard, section "Overseas Education", Roberto Bruzzone, co-director of HKU-Pasteur Research Pole, explains the attraction of French research and education in life sciences and points out the excellent opportunity it represents for students and young researchers from Hong Kong. The article also displays the experience of a postdoctoral fellow from Hong Kong who have obtained a full-time research position at Institut Pasteur Paris.

Download the article here.

01 Feb 2016

On the move! congratulations and all the best to Tami Zhang who joins Institut Pasteur Paris

Zhang Jingshu Tami has been enrolled as a Postdoc Fellow for a joint project between HKU-Pasteur and Institut Pasteur Paris. The project is funded by Institut Pasteur trough its Projets Transversaux de Recherche (PTR) grant and focuses on the interaction between influenza viral polymerase and host ubiquitin-proteasome system.

She will conduct her experiments in the coming 18 months in the Department of Virology, Institut Pasteur, Paris, in the Molecular genetics of RNA Viruses lab headed by Sylvie van der Werf, under the supervision of Caroline Demeret and Sumana Sanyal.

Tami joined Sumana Sanyal’s team at HKU-Pasteur Research Pole in 2014. She and her colleagues have recently discovered the lipophagy induced by a Type-III membrane protein during dengue virus infection. The manuscript is in preparation.

Tami's goodbye with the HKU-PRP team on January 29, 2016. Tami is the third from the left.

01 Feb 2016

HKU-Pasteur Research Pole introduces a newcomer in the tuning of TCR signaling pathway

Dr Sumana Sanyal and her team at HKU Pasteur Research Pole, in collaboration with colleagues from the Whitehead Institute for Biomedical Research/MIT in Cambridge have published a new study in the Proceedings of the National Academy of Sciences of the USA (PNAS, published online before print on January 25, 2016).

What maintains the magnitude and duration of signaling in T lymphocytes? It is already known that a large number of post-translational modifications regulate the cell fate from engagement of the T-cell receptor (TCR) to transcription of genes associated with the immune response. Among others, phosphorylations, dephosphorylations, calcium signaling, translocation of transcription factors… and of course ubiquitylations and deubiquitylations play a significant role. The current research aimed at identifying deubiquitylating enzymes that participate in this pathway. Deubiquitylation is the removal of a small protein, ubiquitin, or a chain of ubiquitin molecules, conjugated to substrate proteins in order to affect their function: inhibit or enhance protein interactions, modify the proteins cellular location, signal for protein degradation, or adjust proteins activity. While screening for deubiquitylases involved in TCR signaling, the team identified two proteins which had previously never been described in this pathway, as well as two of their substrates: TCR adaptor proteins. They show that one of these deubiquitylation enzyme, the ubiquitin-specific peptidase 12 (Usp12), plays a critical role in maintaining the TCR complex at the cell surface. Hence, the study indicates that deubiquitylases are stakeholders to take on board when considering fine-tuning of signaling cascades.

Proposed model for Usp12 function in the pathway of TCR signaling (Jahan et al. 2016)
 


To find the publication:

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S. PNAS 2016 Jan. doi: 10.1073/pnas.1521763113